Various advantages of HPTLC over HPLC

Both HPTLC and HPLC are well-established for analyte separation and qualitative and quantitative analysis and offer many advantages.

Here are some advantages of HPTLC over HPLC: 

• Preparing samples is easy.
• Low maintenance cost.
• The entire spectrum can be seen.
• Many analysts can work together on the same system.
• Very low solvent consumption per sample.
• The solvent does not require any pretreatment, such as filtration and degassing.
• Samples do not require cleaning.
• A cloudy sample has no effect on the analysis.
• A cloudy sample has no effect on the analysis.
• When using a freshly prepared mobile phase, there is no interference from previous analyses.
• Analytical grade solvents are acceptable.
• No expensive solvents are required.
• UV absorbing and corrosive mobile phases can also be used.
• Great flexibility in each step of mobile phase selection, stationary phase selection, and development techniques.
• More basic pH values ​​can be used for mobile phases that are not suitable for HPLC.
• Analysis requirements are minimum requirements.
• The technology is simple, no need for professionals to learn and operate.
• Pre-coated HPTLC boards are inexpensive.
• The solvent solution is not particularly important for sample solubility because it is completely removed before developing the chromatogram.
• Samples and standards can be processed simultaneously under the same conditions, providing better analytical accuracy and precision.

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