Applications of Thin Layer Chromatography in Pharmaceutical Analysis

Applications of thin layer chromatography in pharmaceutical analysis contain purity testing, identification, stability testing, assay, and content uniformity testing of intermediates, raw materials, and drug products, with the analysis of sample analytes. TLC is dependent on its unique detection, the speed of analysis, flexibility, and simplicity methods on together quantitative and qualitative basis. Often degradation products, synthetic intermediates, and process related impurity they do not have chromophores which cannot be detected by the UV detector. Thus, these types of impurities are frequently specified by the TLC analysis. Sometimes impurities are eluted on the solvent front in the HPLC, and they may be complicated to quantities and monitor, and modify in the mobile phase or HPLC column could not be able to solve them adequately. On the other hand, occasionally the impurities have taken more time to elute from the column, and they can’t be detected, but in TLC method is open in which whole samples are evaluated. Thin layer chromatography use in the early stage of drug development.

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