Advantages and disadvantages of gas-liquid chromatography

01/06/2023

Advantages and disadvantages of gas-liquid chromatography

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  1. Advantages and disadvantages of gas-liquid chromatography
    1. The advantages of gas-liquid chromatography are as follows.

Gas-liquid chromatography is a type of chromatography used for the separation and identification of volatile compounds. The stationary phase consists of small volumes of non-volatile liquid, placed on a finely divided solid inert support, and a mobile phase (carrier gas) is an inert gas such as nitrogen or helium used in gas-liquid chromatography. Gas-liquid chromatography works on the principle of partition. In GC, the vaporized molecules of the sample mixture are split due to the separation between a liquid stationary phase and a gaseous mobile phase that remain in the column.


The advantages of gas-liquid chromatography are as follows.

  • Qualitative and quantitative analysis is possible with high sensitivity in gas-liquid chromatography.
  • The length of the GC column is additional compared to high performance liquid chromatography and therefore the most complex sample mixture can be separated with high resolution.
  • GLC offers high sensitivity, precision and resolving power compared to other chromatographic methods.
  • It can be used with a thermal detector or with a mass detector.
  • Sample analysis is very fast, which saves time.
  • Very small amounts of samples are required for analysis.

The disadvantages of gas-liquid chromatography are as follows.

  • The detectors used in GC are destructive.
  • The disadvantage of FID is that the sample that emanates from the detector cannot be recovered.
  • The main disadvantage of gas-liquid chromatography is that only volatile samples can be analyzed.
  • In HPLC or TLC we can change the composition of the mobile phase, but in GC we cannot change the mobile phase because it has a constant flow of carrier gas.

If you want to know other articles similar to Advantages and disadvantages of gas-liquid chromatography you can visit the category gas chromatography.

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Jose Hullgren (Laboratory Analist)

Hello to all readers, my name is Jose Hullgren, it is a pleasure to present you this website of my authorship, I am currently working as a laboratory analyst and for the last 10 years I have been working in the pharmaceutical industry. The main idea of this page is to provide relevant information in the field of the pharmaceutical industry above all. We also cover different areas of chemistry and sciences in general that we find interesting.Perfil Linkedin

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