Impurities related to stereochemistry in pharmaceutical substances

The most important thing is to see compounds related to stereochemistry, these compounds have the same chemical structure, but there is a different spatial orientation. These types of compounds can be considered impurities in active pharmaceutical ingredients. Chirality can be observed in a molecule containing one or more tetrahedral carbons by four different substances. Chiral molecules can also be due to many different reasons and should be the factor in any assessment of impurities. Chiral molecules are often called enantiomers. Enantiomers are optical isomers with similar chemical structure, but different spatial arrangements.

It is important that they are not ignored because one compound isomer may have different toxicological or pharmacological activity, therefore the unwanted optical isomer is considered a chiral impurity of the active pharmaceutical ingredients. Moreover, it is important to note that the number of chiral impurities increases with the increase in the number of asymmetric carbon atoms in the molecule.

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