Difference Between Dissolution and Solubility

The main difference between dissolution and solubility is that dissolution is a kinetic process, whereby a solid, liquid or gas phase solute dissolves in a solvent to form a solution whereas solubility is the maximum concentration of a solute that can dissolve. in a solvent at a specified temperature, is a thermodynamic process.

Dissolution and solubility are related to each other, but there is a slight disparity between them. Dissolution is the process in which the solute dissolves in the medium (solvent), but solubility is the result of dissolution. In this process, the solid part refers to the solute and the liquid part refers to the solvent. Several factors affect this type of reaction, such as the temperature, the size of the solute, and the properties of the solvent.

Before understanding the difference between dissolution and solubility, it is important to know the three essential components involved in the term dissolution and solubility i.e. solvent, solute and solution.

Solute: A solute is a compound that dissolves in a solvent.

solvent: A solvent is a liquid used to dissolve a solute.

The solution: The mixture formed when a solute dissolves in a solvent is called a solution.

Solutes can be liquid, solid or gaseous, and although solvents are usually liquid, they can also be solid and gaseous.

Some points of differences between dissolution and solubility are given below.

  • Dissolution is the ability of solute to dissolve while solubility is the rate at which solute dissolves in a solution.
  • Dissolution is a kinetic process while solubility is a thermodynamic process.
  • In solution, the solute dissolves in a solvent to form a solution, while solubility is the result of dissolution.
  • Dissolution is measured in mol/s while solubility is measured in mol/kg.
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Dissolution is a kinetic process which is performed by a dissolution test apparatus (USP, IP, BP dissolution apparatus) for oral solid dosage form and used to find the dissolution rate of a solute in a solution, in the meaning that the process is the solutes. always soluble in the medium or solvent.

Factors affecting dissolution:

  • Area
  • Physicochemical properties of the drug
  • process temperature
  • Solute concentration
  • Solvent viscosity and polarity


Solubility is a thermodynamic process in which the chemical property refers to the ability of a given solute, the substance, to liquefy in the solution or solvent. Solubility is used to know the ability of the solute to dissolve in a particular amount of solvent, where solutes in the process are not always soluble in the medium or the solvent depends on the properties of the solute.

Factors affecting solubility:

  • Solute concentration
  • system temperature
  • The polarity of the solvent
  • The polarity of the solute
  • system pressure

The most frequently asked questions about solubility and dissolution are as follows.

How does solubility affect dissolution rate?

Solubility and dissolution rate are two different phenomena. The solubility of the sample in a solvent may be low but its rate of dissolution may be high. A solute, on the other hand, can be very soluble, but it takes a long time to reach its final saturation concentration.

What is the benefit of dissolution testing?

Dissolution can determine the rate of release and degree of absorption of dosage forms, which is an important advantage of dissolution.

What is dissolution in chemistry?

A mechanism by which a solute in liquid, solid or gaseous phase dissolves in a solvent to form a solution is called dissolution.

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