Difference Between Dissolution and Dissociation

📋 Index of contents
  1. Dissolution:
  2. Dissociation:
    1. What factors affect solubility?
    2. What is a disintegration test?
    3. What is miscibility in chemistry?


The term solution is used when ionic compounds dissolve in water, where ions were previously present in a solid state when added to water. for example, NaCl.

"Solution" means the solid dosage form towards formation or dissolution in a medium or solution. As it dissolves, the solute then dissociates into molecules or ions, and each molecule or ion is bound by the solvent molecules. The interaction between solute particles and solvent molecules is called hi.

The dissolution of oral solid dosage forms such as tablets, capsules and caplets, etc. performed in the dissolution apparatus. It is available in different types, such as USP dissolution apparatus, BP dissolution apparatus and IP dissolution apparatus.


The process of separating solute ions, while adding to the solvent, is known as dissociation. This happens while the attraction between the solute ions is very weak compared to the solvent molecules and the solute ions, in this case the solvent closes the solute ion and pulls them away from each other.

Organic compounds such as glucose and sugars, which are molecular compounds, dissolve in water and form H bonds with the water, causing their molecules to dissociate from each other, breaking their structure at the solid state.

The most frequently asked questions are:

What factors affect solubility?

Solute concentration, system temperature, system pressure and solute polarity are the factors that affect solubility.

What is a disintegration test?

Disintegration is a physical process in which small particles of a pill or granular particle are mechanically fragmented.

What is miscibility in chemistry?

Miscibility is the property of two substances to combine/mix in all proportions and form a homogeneous solution, this is called miscibility.

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Jose Hullgren (Laboratory Analist)

Hello to all readers, my name is Jose Hullgren, it is a pleasure to present you this website of my authorship, I am currently working as a laboratory analyst and for the last 10 years I have been working in the pharmaceutical industry. The main idea of this page is to provide relevant information in the field of the pharmaceutical industry above all. We also cover different areas of chemistry and sciences in general that we find interesting. Perfil Linkedin

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