Disintegration and dissolution are the two basic processes used for qualification purposes to improve the bioavailability and solubility of dosage form and to be used in chemical and pharmaceutical field, which are intended to break the strength that substances take together . . Both methods can be used with the same substance. However, dissolution can apply to solids, liquids, and gases, and disintegration applies to large solid substances.
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Disintegration time is a process required to break down the dosage form into the specified size or particles, this process is called disintegration. While dissolution is a kinetic process in which solids dissolve in the solution or dissolution medium, it is controlled by the affinity of the solvent and the solid substance. In other words, disintegration is used to measure the time for a dosage form to break down, and dissolution is used to measure the rate at which a solute or oral dosage form dissolves in a medium or solution. .
Dissolution test:
Dissolution test is used to determine the drug in pharmaceutical products such as tablets, capsules or capsules to prepare any solid oral dosage form according to pharmacopoeias such as USP, BP or IP criteria. Determines adequate bioavailability and provides data for formulation of solid dosage forms.
It is an important analytical procedure that typically provides an active pharmaceutical ingredient (API) release rate and is also used for stability testing, quality control, and batch-to-batch consistency assessment. the other in the pharmaceutical industry. The different types of dissolution apparatus used to perform the dissolution process, such as the rotating basket, paddle type, reciprocating cylinder, flow cell and disk paddle, rotating cylinder and alternate disc, etc.
Disintegration test:
Disintegration tests determine a pill's ability to break down into smaller particles or granules so that the active drug can be absorbed by the body. It is used to measure the rate at which a tablet breaks down into tiny particles, allowing for greater surface area and greater availability of the drug when consumed by the patient. This test is performed using a disintegration test apparatus and may also be available in different forms according to USP/IP/BP.
Difference Between Dissolution and Disintegration:
- Dissolution is the process by which a substance forms a solution while disintegration is a process of breaking down substances into small particles or their constituent parts.
- The dissolution process can only be performed after the low solubility particles have decomposed, while the disintegration process can be performed for a sample whether it has a low or high solubility level.
- The sample to be analyzed in solution can be solid, liquid or gaseous, while the sample to be analyzed in disintegration can only be solid substances.
- The pharmaceutical dissolution test is done using a dissolution apparatus while the disintegration study is done with a disintegration tester.
Difference between disintegration time and dissolution rate:
The time it takes for a dosage form to break down into granules of a specific size under precisely controlled conditions is called the disintegration time, while the dissolution rate is the transfer rate of individual drug molecules from solid particles in solution in the form of loose granules. people. drug molecules.
