What is the work standard in the pharmacy?
Laboratory standard, internal standard and secondary standard are the names of the working standard. It can be used for routine analytical evaluation of active pharmaceutical ingredients or dosage forms under conditions where it is difficult to obtain a high purity analytical reference standard. The working standard is usually specific to the phase of pharmaceutical drug development in which it is used.
The purity of the working standard is usually very high; however, an analytical reference can be assigned without the same stiffness being applied to the reference standard rating. Working standards are often used in place of the analytical reference standard to preserve material. Preferably, the working standard should be prepared by the normal synthetic route used for the manufacture of active pharmaceutical ingredients and subjected to further purification, if necessary.
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