Stability of colloids

Salts are sometimes added to pharmaceutical buffer formulations to maintain the pH necessary for product stability. Sometimes these buffers can give potential instability due to insoluble salts formed with metal ions. This problem can occur especially with phosphate buffers, as most heavy metal phosphates are insoluble.

If this insoluble phosphate salt buffer comes from a colloidal dispersion, it can co-precipitate the particles next to it. To avoid this, one could use chelating operators which in particular respect the metal particles and therefore prevent them from reacting with the phosphate. Non-phosphate buffers could then be replaced with phosphate buffers, if possible, to avoid instability.

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Jose Hullgren (Laboratory Analist)

Hello to all readers, my name is Jose Hullgren, it is a pleasure to present you this website of my authorship, I am currently working as a laboratory analyst and for the last 10 years I have been working in the pharmaceutical industry. The main idea of this page is to provide relevant information in the field of the pharmaceutical industry above all. We also cover different areas of chemistry and sciences in general that we find interesting. Perfil Linkedin

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