Pharma Buffer Applications
Some applications of the buffer solution mentioned here are as follows.
Proteins are purified depending on whether amphoteric compounds are poorly soluble at their isoelectric point. For example, insulin precipitates from an aqueous solution in the pH range of 5 to 6. This technique is used for the purification of insulin.
Due to hydrolysis, many compounds are unstable in aqueous solutions. These solutions can be stabilized by regulating the pH. For example, the stability of vitamins is only within a narrow pH range.
If the pH of the solution is not properly maintained, the drug solution may precipitate. This principle applies to the manufacture of dosage forms, and some pharmaceutical ingredients and drugs only dissolve at a specific pH, so it is necessary to maintain the correct pH of the solution.
Optimization of biological activity:
Enzymes contain most of the activity only at certain pH values. For example, at pH 1.5, pepsin activity is maximal.
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