Pharma Buffer Applications

📋 Index of contents
  1. Some applications of the buffer solution mentioned here are as follows.
    1. Improved Purity:
    2. Increased stability:
    3. Improved solubility:
    4. Optimization of biological activity:

Some applications of the buffer solution mentioned here are as follows.

Improved Purity:

Proteins are purified depending on whether amphoteric compounds are poorly soluble at their isoelectric point. For example, insulin precipitates from an aqueous solution in the pH range of 5 to 6. This technique is used for the purification of insulin.

Increased stability:

Due to hydrolysis, many compounds are unstable in aqueous solutions. These solutions can be stabilized by regulating the pH. For example, the stability of vitamins is only within a narrow pH range.

Improved solubility:

If the pH of the solution is not properly maintained, the drug solution may precipitate. This principle applies to the manufacture of dosage forms, and some pharmaceutical ingredients and drugs only dissolve at a specific pH, so it is necessary to maintain the correct pH of the solution.

Optimization of biological activity:

Enzymes contain most of the activity only at certain pH values. For example, at pH 1.5, pepsin activity is maximal.

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Jose Hullgren (Laboratory Analist)

Hello to all readers, my name is Jose Hullgren, it is a pleasure to present you this website of my authorship, I am currently working as a laboratory analyst and for the last 10 years I have been working in the pharmaceutical industry. The main idea of this page is to provide relevant information in the field of the pharmaceutical industry above all. We also cover different areas of chemistry and sciences in general that we find interesting. Perfil Linkedin

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