Kinetics of drug degradation in pharmaceutical substances
Pharmaceutical degradation reactions occur in chemical nature and at limited rates. The temperature, the solvent, the energy of the radiation, the pH of the medium, the presence of a catalyst and the concentration of the reactants are the factors which influence these reactions. The reaction sequence is the attribute in which the reaction rate depends on the concentration of the reactant.
To make a certain improved stability prophecy, it is important to recognize that the limitations of the experimental heat obtained by the activation values are critical. To calculate the degradation rates at each pH value for different temperatures, the heat of activation must be obtained for all bimolecular rate constants involved in the pH rate profile.
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